![]() Transmission electron microscopy of early stage VT revealed direct blood cell contact with luminal fibrin-rich surfaces. FTP11 localized to the luminal surface of early-stage VT, but only minimally to subacute VT (p<0.001). In both stasis VT and non-stasis VT, NIRF microscopy showed that FTP11 fibrin binding was thrombus age-dependent. Utilizing high-resolution in vivo optical molecular imaging with FTP11, a near-infrared fluorescence (NIRF) fibrin-specific reporter, here we investigated the in vivo interrelationships of blood accessibility to fibrin, thrombus age, thrombus neoendothelialization, and fibrinolysis in murine venous thrombosis (VT). In particular, it is unknown how age-dependent thrombus organization limits direct blood contact with fibrin, the target of blood-based fibrinolytic agents. File import instruction Abstractįibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. Select the file that you have just downloaded and select import option Reference Manager (RIS). #Graphpad prism 8 accessibility downloadAvailable fromĬlick on Go to download the file. ![]() Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study. Stein-Merlob AF, Kessinger CW, Erdem SS, Zelada H, Hilderbrand SA, Lin CP, Tearney GJ, Jaff MR, Reed GL, Henke PK, McCarthy JR, Jaffer FA. ✉ Corresponding author: Farouc Jaffer MD PhD FAHA, MGH CVRC, 185 Cambridge Street, Simches Research Building, Room 3206, Boston, Massachusetts 02114. Current Address: Istanbul Medipol University Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MIĦ. ![]() Department of Medicine, University of Tennessee Health Sciences Centerĥ. ![]() Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical SchoolĤ. Center for Systems Biology, Massachusetts General Hospital, Harvard Medical Schoolģ. Cardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Harvard Medical SchoolĢ. Sibel Erdem 2,6, Henry Zelada 1, Scott A. Research Paper Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging StudyĪshley F. ![]()
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